Regulation of phosphatidic acid phosphatase
نویسندگان
چکیده
منابع مشابه
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
PA2 phosphatase (PAP3; 3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) catalyzes the Mg2 -dependent dephosphorylation of PA, yielding DAG and Pi (Fig. 1) (1–3). In de novo lipid synthesis, the DAG generated from the PAP reaction is utilized for the synthesis of the phospholipids PE and PC via the Kennedy pathway and for the synthesis of TAG (Fig. 1) (3). The enzyme substrate PA is also used fo...
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Signaling from G protein-coupled receptors to phospholipase C-beta (PLC-beta) is regulated by coordinate interactions among multiple intracellular signaling molecules. Phosphatidic acid (PA), a signaling phospholipid, binds to and stimulates PLC-beta(1) through a mechanism that requires the PLC-beta(1) C-terminal domain. PA also modulates Galpha(q) stimulation of PLC-beta(1). These data suggest...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.408.3